Journal
CHEMICAL SCIENCE
Volume 13, Issue 36, Pages 10914-10922Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc02961h
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Funding
- European Research Council [EU project 670986-NoNaCat]
- State of MecklenburgVorpommern
- Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia [375213500]
- China Scholarship Council (CSC) [201906230352]
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Silica supported ultrasmall Ni-nanoparticles can efficiently convert nitriles to primary amines under mild conditions, offering broad applicability and good stability.
Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(ii)nitrate and colloidal silica under air and subsequent reduction in the presence of molecular hydrogen the optimal catalyst is prepared. The prepared supported nanoparticles are stable, can be conveniently used and easily recycled. The applicability of the optimal catalyst material is shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.
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