A review on chiral metal-organic frameworks: synthesis and asymmetric applications

Chiral metal-organic frameworks (CMOFs) have the characteristics of framework structure diversity and functional tunability, and have important applications in the fields of chiral identification, separation of enantiomers and asymmetric catalysis. In recent years, the application of CMOFs has also been extended to other research fields, such as circularly polarized fluorescence and chiral ferroelectrics. Compared with achiral MOFs, the design of CMOFs only considers the modes of introduction of chirality, and also takes into account the crystallization and purification. Therefore, the synthesis and characterization of CMOFs face many difficult challenges. This review discusses three effective strategies for constructing CMOFs, including direct synthesis of chiral ligands, spontaneous resolution of achiral ligands or chiral template-induced synthesis, and post-synthetic chiralization of achiral MOFs. In addition, this review also discusses the recent application progress of CMOFs in chiral molecular recognition, enantiomer separation, asymmetric catalysis, circularly polarized fluorescence, and chiral ferroelectrics.

Automated summary

This review discusses the characteristics, construction strategies, and recent advances in applications of chiral metal-organic frameworks (CMOFs). CMOFs have the characteristics of structural diversity and functional tunability, and find important applications in fields such as chiral identification and enantiomer separation. The review focuses on three effective strategies for constructing CMOFs and summarizes the recent progress in various applications of CMOFs.