Journal
RSC ADVANCES
Volume 12, Issue 39, Pages 25633-25638Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra05009a
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Funding
- Guizhou University Found for Newly Enrolled Talent [[2019]15]
- Guizhou University Found for Cultivation [[2019]65]
- Guizhou Provincial Science and Technology Foundation [[2020]1Y09]
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Polysubstituted phenylisoxazoles were synthesized and found to exhibit improved antibacterial activities, especially the 4-nitro-3-phenylisoxazole derivatives. The compounds showed better inhibitory effects against Xoo, Psa, and Xac compared to the positive control bismerthiazol.
Polysubstituted phenylisoxazoles were designed and synthesized to discover new antibacterial agents via [3 + 2] cycloaddition. Thirty-five compounds with a phenylisoxazole scaffold were characterized by NMR, HRMS, and X-ray techniques. After being evaluated against Xanthomonas oryzae (Xoo), Pseudomonas syringae (Psa), and Xanthomonas axonopodis (Xac), 4-nitro-3-phenylisoxazole derivatives were found to better antibacterial activities. Further studies have shown that the EC50 values of these compounds were much better than that of the positive control, bismerthiazol.
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