4.1 Review

Recent advances of carbon dots as new antimicrobial agents

Journal

SMARTMAT
Volume 3, Issue 2, Pages 226-248

Publisher

WILEY
DOI: 10.1002/smm2.1131

Keywords

antimicrobial; antimicrobial activity; carbon dots; photodynamic effect; reactive oxygen species

Funding

  1. Beijing Municipal High-Level Innovative Team Building Program [IDHT20180504]
  2. Beijing Outstanding Young Scientists Program [BJJWZYJH01201910005017]
  3. National Natural Science Foundation of China [21872001, 51801006, 21805004]
  4. Key Project of the National Natural Science Foundation of China [21936001, 21801092]
  5. Beijing Natural Science Foundation [2192005]
  6. Beijing Municipal Science and Natural Science Fund Project [KM201910005016]

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Carbon dots (CDs), a new type of carbon-based nanomaterials, show great potential as antimicrobial agents due to their unique optical properties, excellent biocompatibility, and easy surface modification. The research on CDs as antimicrobial agents has made significant progress, but there are challenges in terms of repeatable and exact preparation methods, as well as practical antimicrobial activity.
Due to the COVID-19 pandemic, many rapid antimicrobial agents have developed intensively. Carbon dots (CDs), a new type of carbon-based nanomaterials, shows great potential against emerging infectious diseases and antimicrobial-resistant infections due to their unique optical properties, excellent biocompatibility, and easy surface modification. With the definition of the CDs structure and properties, synthesis, and characteristic technology improvement, the research on the CDs as antimicrobial agents has made significant progress. However, the lack of high repeatable and exact preparation methods, and the regular antimicrobial activity make it far from practical application. In this review, we summarize the most recent progress and challenges of CDs antimicrobial. First, an overview of the characteristics and properties is given, and the advantage of CDs applied to antimicrobial is further discussed. Then, it focuses on research progress on antimicrobial mechanisms under different conditions, the critical factors affecting their antimicrobial activity, and the practical antimicrobial applications. Finally, the main challenges and future research perspectives of antimicrobial CDs are proposed.

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