Journal
RESULTS IN CHEMISTRY
Volume 4, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.rechem.2021.100279
Keywords
Aryl aldehydes; Phenyl acetylenes; Amines; TBAI; Propargylamines; Multi-component reaction
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Funding
- Guru Gobind Singh Indraprastha University (GGSIPU)
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A new methodology was developed for the synthesis of propargylamines via A(3) coupling reaction. The reaction showed high yield, shorter reaction duration, and operated smoothly in air without any metal catalyst.
A new and facile methodology was developed for the synthesis of a wide variety of synthetically important propargylamines via the A(3) coupling reaction of aryl aldehydes, phenyl acetylenes, and amines. The reaction was catalyzed by tetra-butyl ammonium iodide (TBAI) in solvent acetonitrile utilizing a multi-component approach. The reaction is unique in the way that it operates smoothly in the air at optimum temperature in shorter reaction duration without any metal catalyst and is high yielding.
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