Recent advances and SAR study of 2-substituted benzothiazole scaffold based potent chemotherapeutic agents

In recent times cancer has become one of the leading causes of death. Globally around 11 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe emergence of drug resistance, side effect, and multidrug-resistant cancers due to mutations, the demand for novel, potent and safe candidates as an anticancer agent possessing diverse mechanisms of action is always there. In medicinal chemistry, over the last decade, various heterocyclic derivatives and their structural hybrids were explored and reported frequently in literature; these derivatives have received substantial attention as anticancer agents. In which nitrogen and sulfur-bearing heterocyclic moiety, Benzothiazole emerged as significant and versatile heterocycles for developing novel anticancer candidates. The medicinal chemist widely explores Aminobenzthiazole, Mercaptobenzthiazole, and 2-arylbenzothiazole in search of potent compounds. Here, in this review, we have covered advances of aminobenzothiazole, mercaptobenzothiazole scaffold bearing derivatives along with their structural hybrids as potent anticancer agents, which have been reported recently. We have also discussed a detailed account of the structure-activity relationship, which will provide a framework for drug discovery and design.

Automated summary

In recent years, cancer has become one of the leading causes of death, and there is a significant demand for novel anticancer agents. Benzothiazole derivatives have received substantial attention in medicinal chemistry as potential anticancer agents. This review discusses the recent advances in aminobenzothiazole and mercaptobenzothiazole derivatives, along with their structural hybrids, as potent anticancer agents. The structure-activity relationship is also explored, providing a framework for drug discovery and design.