Journal
RESULTS IN CHEMISTRY
Volume 4, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.rechem.2022.100336
Keywords
Halogen bond; Powder X-ray diffraction; Solid-state NMR; Mechanochemistry
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
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The cocrystallization of 1,3,5-trichloro-2,4,6-trifluorobenzene, 1,3,5-tribromo-2,4,6-trifluorobenzene, and 1,3,5-triiodo-2,4,6-trifluorobenzene with 2,3,5,6-tetramethylpyrazine was assessed using mechanochemical and solution methods. Instead of single crystals, powder X-ray diffraction and solid-state NMR spectroscopy were used to qualitatively evaluate the formation of halogen-bond induced cocrystals. The results indicate a diverse polymorphic landscape that deserves further study.
Cocrystallization of each of 1,3,5-trichloro-2,4,6-trifluorobenzene, 1,3,5-tribromo-2,4,6-trifluorobenzene, and 1,3,5-triiodo-2,4,6-trifluorobenzene with 2,3,5,6-tetramethylpyrazine via selected mechanochemical and solution methods is assessed. In lieu of single crystals of suitable quality for structure determination via single-crystal Xray diffraction, powder X-ray diffraction and C-13 cross-polarization magic-angle spinning solid-state NMR spectroscopy are used to qualitatively assess halogen-bond induced cocrystal formation. The results suggest a rich polymorphic landscape worthy of further study.
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