Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 29, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12929-022-00854-7
Keywords
Tripartite motif (TRIM); Hepatocellular carcinoma (HCC); Ubiquitination; E3 ubiquitin ligase
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Funding
- National Nature Science Foundation of China [81874065, 81874149]
- National Basic Research Program of China [2020YFA0710700]
- Tongji Hospital (HUST) Fundation for Excellent Young Scientist [2020YQ05]
- first level of the public health youth top talent project of Hubei province
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The TRIM protein family is a versatile and highly conserved group of proteins that function as E3 ligases, regulating the development of hepatocellular carcinoma.
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.
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