Cyclization and Coupling Reactions Promoted by Potassium tert-Butoxide

Over the past few decades, transition metal-catalyzed reactions have been developed into a powerful tool for building various chemical bonds. At the same time, non-metal-promoted chemical bond construction reactions have attracted more and more attention of synthetic chemists because of the avoiding of using expensive metal catalysts and ligands, resulting in the reduce of reaction costs and environmental pollution. It conforms to the concept of green chemistry development. Among them, potassium tert-butoxide-promoted cyclization and coupling reactions have been rapidly developed. The intramolecular cyclization and intermolecular coupling reactions involving potassium tert-butoxide since 2000 are summarized, and the possible reaction mechanisms are elucidated, which can help chemists better understand the development of this field and promote the development of this field.

Automated summary

Transition metal-catalyzed reactions and non-metal-promoted chemical bond construction reactions are two important research directions in the field of chemistry. The potassium tert-butoxide-promoted cyclization and coupling reactions have rapidly developed in recent years, providing new tools and ideas for green chemistry development.