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Recent Advances in Lossen Rearrangement

Journal

CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 42, Issue 7, Pages 2015-2027

Publisher

SCIENCE PRESS
DOI: 10.6023/cjoc202202030

Keywords

Lossen rearrangement; hydroxamic acid; isocyanate; synthesis

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This article systematically summarizes the development and mechanism of Lossen rearrangement, as well as discusses its future research direction and application prospects.
Isocyanate is an important intermediate in organic synthesis, which could be prepared via the reaction of Hoffman rearrangement, Curtis rearrangement or Lossen rearrangement. Considering avoiding the hazardous and potentially explosive reagents, chemists have focused on Lossen rearrangement and made the progress and applications of this reaction. The development and applications of the typical reactions of Lossen rearrangement based on its mechanism are systematically summarized. The direction of future research is also prospected.

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