Recent Advances in Lossen Rearrangement

Isocyanate is an important intermediate in organic synthesis, which could be prepared via the reaction of Hoffman rearrangement, Curtis rearrangement or Lossen rearrangement. Considering avoiding the hazardous and potentially explosive reagents, chemists have focused on Lossen rearrangement and made the progress and applications of this reaction. The development and applications of the typical reactions of Lossen rearrangement based on its mechanism are systematically summarized. The direction of future research is also prospected.

Automated summary

This article systematically summarizes the development and mechanism of Lossen rearrangement, as well as discusses its future research direction and application prospects.