Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 80, Pages 11268-11271Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03713k
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- Council of Scientific & Industrial Research (CSIR), New Delhi
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The study presents the development of a visible-light-driven modular micro-flow reactor for the synthesis of a fused N-heteroaryl scaffold and late-stage functionalization of pyrazolopyridines. The method offers a simple and efficient approach without the need for expensive oxidants or additional photo-catalysts.
Late-stage functionalization (LSF) of active pharmaceutical ingredients can provide a straightforward approach to efficient de novo design and synthesis of drug molecules for structural activity relationship studies (SARS). Herein, we have developed a visible-light-driven modular micro-flow reactor consisting of an integrated post-synthetic work-up that was designed and developed to synthesize a fused N-heteroaryl scaffold and late-stage functionalization of pyrazolopyridines without using any expensive oxidant or additional photo-catalyst (PC).
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