Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 79, Pages 11155-11158Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04548f
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Electrochemical reduction via paired electrolysis is used for the deoxygenative reduction of ketones. The spontaneous beta-scission of phosphoranyl radicals plays a crucial role in the cleavage of C-O bonds.
Electrochemical reduction via paired electrolysis has been used to achieve deoxygenative reduction of ketones. As a result of the complexing of ketones with the triphenylphosphine radical cation generated by anodic oxidation, the reduction of carbonyl groups occurs readily. Through spontaneous beta-scission of phosphoranyl radicals, C-O bonds are cleaved to form benzylic radical intermediates. These radical species are either able to abstract hydrogen from MeCN or undergo reduction at the cathode to give carbanions, upon workup forming reductive hydrogenation of ketones.
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