Journal
FETAL DIAGNOSIS AND THERAPY
Volume 49, Issue 3, Pages 67-76Publisher
KARGER
DOI: 10.1159/000523974
Keywords
Severe acute respiratory syndrome coronavirus 2; COVID-19; First trimester; Preeclampsia; Obstetric outcomes
Categories
Funding
- Stavros Niarchos Foundation [RD16/0022/0015]
- Santander Foundation
- LaCaixa Foundation
- Sant Pau Research Institute
- ISGlobal
- Maternal and Child Health and Development Network (SAMID)
- Instituto de Salud Carlos III
- Spanish Ministry of Health
Ask authors/readers for more resources
First-trimester SARS-CoV-2 infections are mostly asymptomatic, with a slight increase in inflammatory markers in symptomatic women. Obstetric complications were not increased, but PAPP-A levels were higher in symptomatic women.
Objective: Second- and third-trimester SARS-CoV-2 infections may have an increased risk of obstetric complications. However, data on first-trimester infections are scarce. We sought to characterize the clinical and inflammatory presentations and pregnancy outcomes of first-trimester infections. Methods: A population-based multicenter study including 817 singleton pregnancies with SARS-CoV-2 serologic testing at 8-14 weeks between March and May 2020. Blood count, uterine artery Doppler, and pregnancy-associated plasma protein A (PAPP-A) were performed in all women. Placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), IL-6, and ferritin were determined in positive women. Obstetric outcomes were evaluated. Results: The prevalence of first-trimester infection was 15.2% (n = 124). 72.6% of positive women were asymptomatic. Symptomatic women had higher rates of lymphopenia (1.91 x 10(9)/L vs. 2.16 x 10(9)/L, p = 0.017) and increased levels of IL-6 (9.1% vs. 1.2%, p = 0.051), but lower rates of decreased ferritin (6.3% vs. 19.8%, p = 0.015). PAPP-A was higher in symptomatic women compared with asymptomatic and negative women (1.44 [IQR 0.90-1.82] vs. 1.08 [IQR 0.66-1.61] p = 0.014, vs. 1.08 [IQR 0.77-1.55] p = 0.019, respectively). Obstetric outcomes were not increased. Conclusions: First-trimester SARS-CoV-2 infections are mostly asymptomatic, with a mild increase of inflammatory markers in symptomatic women. Obstetric complications were not increased, but PAPP-A levels were higher in symptomatic women.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available