Journal
2022 45TH INTERNATIONAL SPRING SEMINAR ON ELECTRONICS TECHNOLOGY (ISSE)
Volume -, Issue -, Pages -Publisher
IEEE
DOI: 10.1109/ISSE54558.2022.9812787
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Funding
- Doctoral Student Scholarship Program of the Cooperative Doctoral Program of the Ministry for Innovation and Technology from the source of the National Research, Development, and Innovation Fund
- ISTH
- Hungarian National Research Development and Innovation Office (NFKI) [OTKA-K19_131945]
- National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-02]
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The study aims to investigate the effect of shear stress on the activation of vWF using designed microfluidic chambers. Numerical simulations were conducted on different three-dimensional microfluidic system models to understand the flow field and shear stress between fluids of different densities and dynamic viscosities.
Von Willebrand factor (vWF) is the largest glycoprotein in blood, which plays a major role in primary haemostasis via its interaction with endothelial cell surface receptors and platelets. Altered shear stress value can cause conformational unfolding of vWF, which leads to the activation of the factor. The primary aim of this work is to study the effect of shear stress on the activation of vWF with the designed microfluidic chambers. Numerical simulations were performed on different three-dimensional microfluidic system models, including two input channels converging and forming a single output. In this work, the flow field, the occurring shear stress, and velocity between the two fluids with different densities and dynamic viscosities were investigated. The numerical simulations are necessary to understand the flow field and the shear stress, which affect the factor.
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