4.7 Review

Recent advances in Ti-based MOFs in biomedical applications

Journal

DALTON TRANSACTIONS
Volume 51, Issue 39, Pages 14817-14832

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt02470e

Keywords

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Funding

  1. Featured Innovation Project of Guangdong Province [2019KTSCX052, 2019KTSCX053]
  2. Key scientific research project of Colleges and Universities of Education Department of Guangdong Province [20202ZDZX2046, 2021ZDZX2052, 2022ZDZX2022]
  3. Panfeng 100 Joint Training Program of Guangdong Medical University [PF100-1-03]
  4. Guangdong Medical University Research Project [1019K20220003]
  5. Guangdong Province Universities and Colleges Pearl River Scholar Fund
  6. Special Funds for Scientific Technological Innovation of Undergraduates in Guangdong Province [pdjh2021b0227, pdjh2021a0218, pdjh2022b0225, pdjh2022b0224]
  7. Medical Scientific Research Foundation of Guangdong Province [A2021208]
  8. Guangdong Basic and Applied Basic Research Foundation [2020A1515110902]
  9. ICMR, New Delhi, India

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Metal-organic frameworks (MOFs), including titanium-based MOFs (Ti-MOFs), have gained significant attention for their wide range of applications. However, the development of MOF materials for biological applications is still an emerging field. This study reviews the recent research progress on Ti-MOFs in therapeutic areas such as antibacterial, oncology, anti-inflammation, and bone injury, providing new directions for further research in the biomedical field.
Currently, metal-organic frameworks (MOFs), basically inorganic-organic hybrid materials, have gained tremendous attention due to their vast applications. MOFs have shown enormous applications in almost every research field. However, the area of designing MOF materials for their biological applications is still an emerging field that needs attention. Titanium-based metal-organic framework (Ti-MOF) materials are used in many research areas due to their structural advantages, such as small particle size and large effective surface area. On the other hand, they have also shown unique advantages such as good biocompatibility, excellent catalytic oxidation and photocatalytic properties and ease of functionalization. This study reviews the recent research progress on Ti-MOFs in therapeutic areas such as antibacterial, oncology, anti-inflammation, and bone injury, which will provide new directions for further research in this biomedical field. Therefore, this article will help scientists working in the particular field to enhance their understanding of Ti-based MOFs for functional biomedical applications.

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