Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 80, Pages 11312-11315Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03319d
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- CSIR [HCP-23]
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A catalytic oxidative addition of sulfoximines to naphthoquinones via C-H functionalization has been achieved using an iron catalytic system. It shows good reactivity and high regioselectivity in the presence of visible light. This study provides an efficient protocol for obtaining (naphtho)quinone-sulfoximine hybrid analogs in moderate to good yields with a wide scope for substrates. The protocol has also been successfully applied to the modification of natural products.
A catalytic oxidative addition of sulfoximines to naphthoquinones via C-H functionalization has been achieved using an iron catalytic system, which exhibits good reactivity and high regioselectivity in the presence of visible light. This is the first report offering an efficient protocol for obtaining (naphtho)quinone-sulfoximine hybrid analogs in moderate to good yields with wide scope for both the substrates. This protocol has also been applied on natural products for their modification, including vitamin K3, Juglone and some other modified natural scaffolds as well.
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