Journal
COMPTES RENDUS CHIMIE
Volume 25, Issue -, Pages 445-476Publisher
ACAD SCIENCES
DOI: 10.5802/crchim.153
Keywords
Dermatology; Calcification; Vibrational spectroscopies; Electronic microscopy; Syn-chrotron radiation
Categories
Funding
- Fondation pour la Recherche Medicale
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Characterization of skin deposits associated with various skin diseases using different physico-chemical techniques provides an opportunity to improve diagnosis, understand pathogenesis, and explore therapeutic interventions.
Although numerous pathologies are associated with abnormal skin deposits, these remain poorly described, as accurate characterization continues to present a challenge for dermatologists. Their submicrometer size as well as their diverse chemistry require various characterization tools. We aim to exemplify characterization of endogenous and exogenous skin deposits in some selected skin diseases using different physico-chemical techniques. We begin with a presentation of selected dis-eases associated with skin deposits. We then present those of our results which show their variety of structure, location and chemical composition, obtained with various tools: Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy, X-ray fluorescence, vibra-tional spectroscopies, as well as techniques specific to synchrotron radiation. Our results constitute a real opportunity to improve diagnosis, and to understand the pathogenesis of many skin diseases, and opportunities for therapeutic intervention.
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