Journal
GREEN CHEMISTRY
Volume 24, Issue 20, Pages 7996-8004Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc02548e
Keywords
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Funding
- COLCIENCIAS [110274558597, RC-007-2017]
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An ecofriendly and efficient method for the synthesis of new pharmacologically active 6-arylphenanthridines has been developed using inexpensive starting materials and consecutive reactions under microwave assistance and a catalytic system, resulting in moderate to excellent yields.
An ecofriendly, efficient method for the synthesis of new pharmacologically active 6-arylphenanthridines has been developed for the first time. This method involves consecutive microwave-assisted Suzuki-Miyaura and Pictet-Spengler processes starting from inexpensive available 2-bromoaniline derivatives and 3,4-dimethoxyphenylboronic acid to be easily converted into 2-aminobiphenyl precursors, which react smoothly with diverse aromatic aldehydes to provide valuable polyfunctionalized 6-arylphenanthridines in moderate to excellent yields (45-98%) using a zinc chloride/[Bmim]BF4 mixture as both a useful catalytic system and reaction medium.
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