Synthesis of Glycoluril Dimers with the Ability to Form Polymeric Self-Associates in Water

Supramolecular self-assembly in water resulting in polymeric structures is emerging because of its potential in the preparation of adaptive materials with applications in biology and medicine. Here, we report the first example of host molecules based on glycoluril dimers, which self-associate into linear oligomers in water. The degree of polymerization for the resulting supramolecular aggregates was calculated using the isodesmic model and the Carothers equation. The model compound was prepared to enable a deeper understanding of the forces responsible for the self-association of the glycoluril dimer-based monomers in water.

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Supramolecular self-assembly in water, leading to polymeric structures, has potential applications in biology and medicine. In this study, we report the self-association of host molecules based on glycoluril dimers into linear oligomers in water. The polymerization degree of the resulting supramolecular aggregates was calculated using the isodesmic model and Carothers equation. A model compound was prepared for a better understanding of the forces responsible for the self-association of glycoluril dimer-based monomers in water.