Journal
BIOMIMETICS
Volume 7, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/biomimetics7030092
Keywords
flexor tendon; tendon adhesion; biomechanics; collagen deposition
Funding
- National Natural Science Foundation of China [82172408, 81772314, 81922045]
- Outstanding Academic Leaders (Youth) project of Shanghai Science and Technology Innovation Action Plan [21XD1422900]
- Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University Medical College Two-hundred Talent Program [20191829]
- Second Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang [SHDC2020CR4032]
- Shanghai Engineering Research Center for Orthopedic Material Innovation and Tissue Regeneration [20DZ2254100]
- Qingfeng Scholar for student Scientific Research Program of Shanghai Medical College, Fudan University [QF 1918]
- Original Exploration project of Shanghai Science and Technology Innovation Action Plan
- Principle Investigator Innovation Team of Both Shanghai Sixth People's Hospital [22ZR1480300]
- Shanghai Institute of Nutrition and Health
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This study aims to create a simplified model for tendon adhesion without sutures in the murine flexor tendon. The experimental results show that this model can mimic classical tendon repair models without significant side effects on biomechanics.
Peritendinous adhesion (PA) around tendons are daunting challenges for hand surgeons. Tenotomy with various sutures are considered classical tendon repair models (TRM) of tendon adhesion as well as tendon healing. However, potential biomimetic therapies such as anti-adhesion barriers and artificial tendon sheaths to avoid recurrence of PA are sometimes tested in these models without considering tendon healing. Thus, our aim is to create a simplified model without sutures in this study by using three 6 mm longitudinal and parallel incisions called the longitudinal incision model (LCM) in the murine flexor tendon. We found that the adhesion score of LCM has no significant difference to that in TRM. The range of motion (ROM) reveals similar adhesion formation in both TRM and LCM groups. Moreover, mRNA expression levels of collagen I and III in LCM shows no significant difference to that in TRM. The breaking force and stiffness of LCM were significantly higher than that of TRM. Therefore, LCM can imitate flexor tendon adhesion formation without sutures compared to TRM, without significant side effects on biomechanics with an easy operation.
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