Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 2, Issue 2, Pages 142-151Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00377
Keywords
topography; stem cells; differentiation; plant virus; biomaterials
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Funding
- National Natural Science Foundation of China [21429401, 21374119]
- US NSF [CHE-1307319]
- University of South Carolina
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1307319] Funding Source: National Science Foundation
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Adult stem cell research has been advanced in recent years because of the cells' attractive abilities of self renewal and differentiation. Topography of materials is one of the key features that can be harnessed to regulate stem cell behaviors. Stem cells can interact with underlying material through nanosized integrin receptors. Therefore, the manipulation of topographical cues at a nanoscale level can be employed to modulate the cell fate. In this review, we focus our discussion on the different surface topographical cues, especially, with an emphasis on the viral nanoparticle-coated materials, and their effects on stem cell differentiation.
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