Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 2, Issue 12, Pages 2133-2138Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00614
Keywords
3D bioprinting; paramagnetism; cell magnetophoresis; fluid recirculation
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada Discovery Grant (NSERC-DG) [RGPIN-2014-04066]
- Canada Foundation for Innovation John R. Evans Leaders Fund (CFI-JELF)
- Ontario Research Fund Research Infrastructure (ORF-RI) grants [33016]
- Fraunhofer-McMaster Project Center for Biomedical Engineering and Advanced Manufacturing (BEAM)
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Using whole blood, we demonstrate the first realization of a novel macroscale, contactless, label-free method to print in situ three-dimensional (3D) cell assemblies of different morphologies and sizes. This novel bioprinting method does not use nozzles that can contaminate the cell suspension, or to which cells can adhere. Instead, we utilize the intrinsic diamagnetic properties of whole blood cells to magnetically manipulate them in situ in a nontoxic paramagnetic medium, creating (a) rectangular bar, (b) three-pointed star, and (c) spheroids of varying sizes. We envision the technique to be transferable to other cell lines, with potential applications in tissue engineering and drug screening.
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