A Tiny BLE Platform for Wireless Brain Monitoring and Optogenetics Stimulation

We present a small headstage enabling multichannel neural recording and optogenetics stimulation in freely moving laboratory mice. The headstage incorporates a new 0.13-mu m system-on-chip (SoC) featuring all the circuitry needed for performing multichannel optogenetic stimulation and multichannel brain recording. The SoC has 10 multimodal recording channels and a 2-ch LED drivers. Digitization is done using in-channel Delta Sigma MASH 2-1 ADC with on-chip decimation. The headstage incorporates a Bluetooth-low-energy (BLE) transceiver along with a Cortex-M4 processor. The system weights 1.24 g with the battery (0.5 g w/o battery), has an autonomy of 150 minutes, and occupies a volume of 0.65 cm(3), making it the smallest BLE electro-optic devices for freely moving brain research. We report in vivo results obtained in the hippocampus of a mouse.

Automated summary

We present a small headstage that allows for multichannel neural recording and optogenetic stimulation in freely moving laboratory mice. The device is compact and lightweight, making it the smallest BLE electro-optic device for freely moving brain research. In vivo experiments conducted in the hippocampus of a mouse demonstrated successful results.