Journal
GREEN CHEMISTRY
Volume 24, Issue 19, Pages 7382-7387Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc01905a
Keywords
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Funding
- ARC [FT180100260, DP200100063]
- UNSW Sydney
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The conversion of nitriles into amines, imines or amides is an important chemical transformation in synthetic laboratories and industrial chemistry. This study developed a new organocatalytic approach using pinacolborane to reduce nitriles, imines or amides to amines. Valuable derivatives can be conveniently obtained through further functionalization reactions.
The conversions of nitriles, readily available synthetic precursors, into amines, imines or amides are important chemical transformations in both synthetic laboratories and industrial chemistry. There have been a diverse range of methods to promote this type of chemistry; however, a number of limitations still exist. In pursuit of a practical and environmentally benign nitrile hydroboration reaction, we developed a new organocatalytic approach to reduce nitriles, imines or amides with pinacolborane to amines. Valuable derivatives from these amines could be conveniently accessed by introducing further functionalization reactions to crude hydroboration mixtures in one pot.
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