Journal
STEM CELL REPORTS
Volume 6, Issue 1, Pages 1-8Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2015.11.013
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Funding
- Japan Science and Technology-California Institute for Regenerative Medicine Collaborative Program
- Japan Society for the Promotion of Science (SPS)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- A-MED
- Grants-in-Aid for Scientific Research [26713047] Funding Source: KAKEN
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Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.
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