Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 82, Pages 11551-11554Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04585k
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Funding
- [EU-H2020]
- [795091]
- [IR INFRANALYTICS FR2040]
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Chemically assisted swapping of labile protons by deuterons is demonstrated for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are investigated using H-1-H-2 isotope correlation NMR spectroscopy (iCOSY). A minute concentration of dopamine, 5 wt% or approximately 100 μg, in a solid formulation can be detected by H-2 NMR at 28.2 T (H-1, 1200 MHz) in under a minute.
Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by H-1-H-2 isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or similar to 100 mu g, in a solid formulation can be detected by H-2 NMR at 28.2 T (H-1, 1200 MHz) in under a minute.
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