Journal
MOLECULES
Volume 27, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/molecules27186061
Keywords
Auricularia auricula polysaccharide (AAP); hypoglycemic activity; gut microbiota; antioxidant capacity
Funding
- National Natural Science Foundation of China [32172171]
- Project of Shaanxi Provincial Department of Agriculture [NYKJ-2021-XA-003]
- Special Scientific Research Program of Shaanxi Provincial Education Department [21JK0634]
- Science and Technology Plan Project of Xi'an Weiyang District [202037]
Ask authors/readers for more resources
The polysaccharides of Auricularia auricula (AAP) have been found to improve type 2 diabetes by altering the gut microbiota in mice. AAP intervention can lower blood glucose levels, improve glucose tolerance, and reduce oxidative stress injury. Furthermore, AAP can regulate the abundance of beneficial and pathogenic bacteria, influencing the structure of the gut microbiota.
In previous studies, Auricularia auricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear. In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes. We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention. Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury. AAP-M (200 mg/kg/d) displayed the best improvement effect. Moreover, 16S rRNA results showed that AAP decreased the abundance of Firmicutes and increased that of Bacteroidetes. The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP. AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter. In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available