Expression and clinical significance of RAG1 in myelodysplastic syndromes

Article Hematology

Comprehensive bioinformatics analysis reveals the hub genes and pathways associated with multiple myeloma

Shengli Zhao et al.

Summary: This study explores the molecular mechanisms of multiple myeloma (MM) using genomics and identifies potential biomarkers for disease diagnosis.

HEMATOLOGY (2022)

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Article Hematology

Bioinformatics analysis deciphering the transcriptomic signatures associated with signalling pathways and prognosis in the myelodysplastic syndromes

Niluopaer Tuerxun et al.

Summary: This study integrated multiple datasets and used bioinformatics methods to analyze the transcriptomic profiles of MDS. Key hub genes, gene clusters, and genes associated with prognosis and diagnosis were identified. The findings provide important clues for the treatment and diagnosis of MDS patients.

HEMATOLOGY (2022)

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Article Oncology

RAG enhances BCR-ABL1-positive leukemic cell growth through its endonuclease activity in vitro and in vivo

Meng Yuan et al.

Summary: The collaboration between BCR-ABL1 and RAG recombinase promotes cell survival, increases double-strand breaks, activates the non-homologous end joining pathway, and decreases sensitivity to tyrosine kinase inhibitors in BCR-ABL1(+) leukemia.

CANCER SCIENCE (2021)

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Review Immunology

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Jennifer J. Trowbridge et al.

Summary: The aging population requires new therapeutic strategies to improve hematopoietic aging disorders; dysregulation of innate immune and inflammatory signaling leads to competitive advantage and clonal dominance; emerging concepts will reveal critical biology and therapeutic opportunities.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Cell Biology

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

Rupa Kumari et al.

Summary: The study showed that miR-29c regulates RAG1 in a B cell stage-specific manner, modulation of miR-29c levels affects V(D)J recombination efficiency in pre-B cells, and a negative correlation between miR-29c and RAG1 levels is observed in different developmental stages.

CELL REPORTS (2021)

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Article Medicine, General & Internal

Clinical Significance of Decreased GPX1 Expression in Patients with Acute Myeloid Leukaemia (Non-M3)

Xiaolin Liang et al.

Summary: In patients with acute myeloid leukaemia (AML), downregulation of GPX1 expression may be closely associated with AML pathogenesis and chemoresistance, leading to lower remission rates and poorer long-term survival outcomes for those with high GPX1 expression levels.

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN (2021)

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Article Oncology