Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 8, Pages 2322-2332Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.04.013This
Keywords
Dry AMD; Wet AMD; Anti-VEGF agents; Port delivery system; Biosimilars; Bispecific antibodies; Gene therapy
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Funding
- Finnish Cultural Foundation
- Olavi Martelius foundation
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This review highlights the current progress and future perspectives of novel and investigational therapeutic strategies for age-related macular degeneration (AMD). For wet AMD, biologics with dual functionalities and combined therapies with long-acting capabilities are expected to lead the drug pipeline, while significant breakthroughs are yet to be made for dry AMD.
Age-related macular degeneration (AMD) is a macular degenerative eye disease, the major cause of irreversible loss of central vision. In this review, we highlight current progress and future perspectives of novel and investigational therapeutic strategies in the drug pipeline, including anti-vascular endothelial growth factor (VEGF) agents, bispecific antibodies, biosimilars, small molecules, gene therapy, and long-acting drug delivery strategies for both dry and wet AMD. We anticipate that biologics with dual functionalities and combined therapies with long-acting capabilities will lead the wet AMD pipeline. Sustained-release platforms also show potential. However, significant breakthroughs are yet to be made for dry AMD. The personalized approach might be well suited in the scenario of diverse genetic variations in both conditions.
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