Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 18, Issue 15, Pages 5885-5896Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.78997
Keywords
organotypic tissue slice culture; anticancer drug discovery; individualized treatment; precision oncology
Categories
Funding
- University of Macau [CPG 2021-00021-FHS, MYRG 2017-00113-FHS, MYRG 2018-00070-FHS, MYRG2019-00067-FHS]
- Science and Technology Development Fund, Macau SAR [094/2015/A3, 122/2016/A3, 018/2017A1, 0011/2019/AKP, 0112/2019/A2, 0034/2019/AGJ, 048/2019/A1]
- Shenzhen Science and Technology Innovation Committee [EF040/FHS-DCX/2021/SZSTIC]
- Natural Science Foundation of China [32070681, 82030094]
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Organotypic tissue slice culture has numerous advantages in anticancer drug development, including the preservation of cell repertoire, quick assessment of therapeutic efficacy, and the ability to select personalized treatment regimens. It is expected to become a potent platform for individualized drug screening.
Organotypic tissue slice culture is established from animal or patient tissues and cultivated in an in vitro ecosystem. This technique has made countless contributions to anticancer drug development due to the vast number of advantages, such as the preservation of the cell repertoire and immune components, identification of invasive ability of tumors, toxicity determination of compounds, quick assessment of therapeutic efficacy, and high predictive performance of drug responses. Importantly, it serves as a reliable tool to stratify therapeutic responders from nonresponders and select the optimal standard-of -care treatment regimens for personalized medicine, which is expected to become a potent platform and even the gold standard for anticancer drug screening of individualization in the near future.
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