Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 83, Pages 11625-11636Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04434j
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Funding
- National Science Foundation [CHE-2108722]
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This article describes the strategies for association of coiled-coil building blocks and their biomedical applications. These systems have proven to be useful in protein storage, cargo binding and delivery, three-dimensional cell culturing, and vaccine development, showing high promise for significant biomedical impact.
Extensive research has gone into deciphering the sequence requirements for peptides to fold into coiled-coils of varying oligomeric states. More recently, additional signals have been introduced within coiled-coils to promote higher order assembly into biomaterials with a rich distribution of morphologies. Herein we describe these strategies for association of coiled-coil building blocks and biomedical applications. With many of the systems described herein having proven use in protein storage, cargo binding and delivery, three dimensional cell culturing and vaccine development, the future potential of coiled-coil materials to have significant biomedical impact is highly promising.
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