Searching for the simplest self-assembling dendron to study helical self-organization and supramolecular polymerization

dendron, Structural simplicity The first generation self-assembling dendron (4Bp-3,4)nG1CO 2 CH 3 where Bp is biphenyl, n is an achiral linear, n -dodecyl, or branched chiral alkyl group, ( S )-3,7-dimethyl-octyl (dm8 *) undergoes helical selforganization in bulk state and in solution. The supramolecular columns assembled from this dendron are helical, regardless, if the alkyl groups on its periphery are achiral or chiral. This demonstrates selforganization of helical columns both from achiral and chiral dendrons and reveals that the role of the stereocenter is to select the helical sense of an already helical column. This very simple self-assembling dendron can be subjected to a large diversity of chemical modifications and functionalization, all expecting to maintain the helical function in bulk and in solution in the range of temperature of interest to investigate helical self-organization and supramolecular polymerization.

Automated summary

This article introduces the structural simplicity and versatility of the first generation self-assembling dendron, which shows potential in investigating helical self-organization and supramolecular polymerization.