Journal
BIOMEDICAL OPTICS EXPRESS
Volume 13, Issue 9, Pages 4583-4591Publisher
Optica Publishing Group
DOI: 10.1364/BOE.464875Journal
Keywords
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Funding
- Israel Science Foundation [990/19]
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By using spectrally encoded flow cytometry (SEFC), we can image the deformations of red blood cells in human capillaries, reflecting their true physiological conditions at these important locations.
Red blood cells in small capillaries exhibit a wide variety of deformations that reflect their true physiological conditions at these important locations. By applying a technique for the high-speed microscopy of flowing cells, termed spectrally encoded flow cytometry (SEFC), we image the light reflected from the red blood cells in human capillaries, and propose an analytical slipper-like model for the cell morphology that can reproduce the experimental in vivo images. The results of this work would be useful for studying the unique flow conditions in these vessels, and for extracting useful clinical parameters that reflect the true physiology of the blood cells in situ.
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