4.6 Review

Gold nanocluster composites: preparation strategies, optical and catalytic properties, and applications

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Efficient fluorescence resonance energy transfer-based ratiometric fluorescent probe for detection of dopamine using a dual-emission carbon dot-gold nanocluster nanohybrid

Yuanyuan Zhang et al.

Summary: A ratiometric fluorescent probe based on fluorescence resonance energy transfer (FRET) was developed for the fluorometric determination of dopamine (DA). The probe, CQDs-AuNCs, exhibited high sensitivity and selectivity towards DA with a detection limit of 2.66 nM, and demonstrated good anti-interference ability, making it suitable for measuring dopamine in serum samples.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2021)

Article Chemistry, Physical

Au Clusters on Pd Nanosheets Selectively Switch the Pathway of Ethanol Electrooxidation: Amorphous/Crystalline Interface Matters

Fan Lv et al.

Summary: A novel 2D Pd-Au heterogeneous catalyst with enhanced C1 selectivity for efficient ethanol oxidation was designed through phase and interphase engineering. The catalyst showed improved selectivity for the C1 pathway and robust stability after accelerated degradation testing.

ADVANCED ENERGY MATERIALS (2021)

Article Oncology

Plasma cell marker, immunoglobulin J polypeptide, predicts early disease-specific mortality in HPV plus HNSCC

Shanying Gui et al.

Summary: This study found that IGJ is a robust and independent prognostic biomarker for disease-specific mortality in HPV+ HNSCC. Patients with low IGJ have a significantly increased risk of disease-specific death and can effectively identify early disease-specific mortality.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Biotechnology & Applied Microbiology

Heavy metal water pollution: A fresh look about hazards, novel and conventional remediation methods

Camilo Zamora-Ledezma et al.

Summary: The article discusses the causes of water pollution, the potential risks of heavy metal contamination to the environment and human health, and the technologies and materials available for purifying water sources. It highlights the human activities as the main source of heavy metals, the health hazards posed by them, and various detection and removal methods.

ENVIRONMENTAL TECHNOLOGY & INNOVATION (2021)

Article Chemistry, Physical

Fluorescent gold nanoclusters stabilized on halloysite nanotubes: in vitro study on cytotoxicity

Maksim Gorbachevskii et al.

Summary: Fluorescent gold nanoclusters (AuNCs) stabilized with 11-mercaptoundecanoic acid and supported on halloysite nanotubes modified with aminosilane showed good uptake by A549 human cells. At concentrations of 25-50 μg/mL, the material did not have a pronounced toxic effect but led to massive cell death via apoptosis at 100 μg/mL. This concentration-dependent toxicity mechanism allows for potential applications in bioimaging and cancer therapy.

APPLIED CLAY SCIENCE (2021)

Review Chemistry, Physical

Recent developments on fluorescent hybrid nanomaterials for metal ions sensing and bioimaging applications: A review

Vaibhavkumar N. Mehta et al.

Summary: This article discusses the importance of integrating fluorescent nanomaterials with analytical tools, introduces the applications of fluorescent nanomaterials in the analysis of metal ions and cell bioimaging, and emphasizes their advantages such as high selectivity, sensitivity, and low detection limits.

JOURNAL OF MOLECULAR LIQUIDS (2021)

Article Engineering, Chemical

Novel fluorescent nanocellulose hydrogel based on gold nanoclusters for the effective adsorption and sensitive detection of mercury ions

Xia Lei et al.

Summary: A novel fluorescent nanocellulose hydrogel with high adsorption capacity for mercury ions and high sensitivity and selectivity for detection was developed in this study. The nanoclusters and nanocrystals in the hydrogel played critical roles in the adsorption process. Therefore, this hydrogel shows great potential for the removal of mercury ions from wastewater.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2021)

Article Chemistry, Analytical

Electrochemiluminescence paper-based screen-printed electrode for HbA1c detection using two-dimensional zirconium metal-organic framework/Fe3O4 nanosheet composites decorated with Au nanoclusters

Anita Ahmadi et al.

Summary: An immunosensor using a sandwich paper-based electrochemiluminescence (ECL) biosensor for detecting glycated hemoglobin has been developed, demonstrating desirable assay performance with a wide response range and low detection limit.

MICROCHIMICA ACTA (2021)

Article Chemistry, Analytical

A visualized ratiometric fluorescence sensing system for copper ions based on gold nanoclusters/perovskite quantum dot@SiO2 nanocomposites

Wanying Xue et al.

Summary: This study introduces an optical sensor for detecting Cu2+ using a ratiometric comparison of red and green fluorescence. The sensor allows for rapid, sensitive, and visualized detection of Cu2+, which has been validated for use in human serum and environmental water samples.

ANALYST (2021)

Article Chemistry, Analytical

Ultrasensitive glucose detection from tears and saliva through integrating a glucose oxidase-coupled DNAzyme and CRISPR-Cas12a

Caiying Zhang et al.

Summary: The study proposes a novel ultrasensitive method for glucose detection utilizing glucose oxidase, DNAzyme, and CRISPR-Cas12a system. By converting glucose signals to nucleic acids through a series of reactions, fluorescence signals are produced for accurate detection of glucose from secretory clinical samples.

ANALYST (2021)

Article Chemistry, Multidisciplinary

Fabrication of a chiral luminescent hydrogel from gold nanoclusters via molecular recognition

Junxiao Liu et al.

Summary: A novel supramolecular chiral hydrogel with enhanced emission was successfully obtained through the co-assembly of achiral thiobarbituric acid-modified gold nanoclusters with chiral histidine molecules. Chirality transfer in the supramolecular hydrogels was achieved through pi-pi stacking and intermolecular H-bonding based on molecular recognition, providing a creative strategy for building chiral nanocluster-based materials.

CHEMICAL COMMUNICATIONS (2021)

Review Chemistry, Multidisciplinary

Electrocatalysis of gold-based nanoparticles and nanoclusters

Chunjie Li et al.

Summary: Gold-based nanomaterials, including nanoparticles and nanoclusters, have great potential as non-platinum electrocatalysts. The controlled synthesis and microstructure adjustment of these materials are crucial in regulating their catalytic activity. This review discusses the latest progress in the synthesis of efficient Au-based NP and NC electrocatalysts and highlights the relationship between Au nanostructures and their catalytic activity.

MATERIALS HORIZONS (2021)

Article Chemistry, Multidisciplinary

The screening of drug-induced nephrotoxicity using gold nanocluster-based ratiometric fluorescent probes

Qin Liu et al.

Summary: A ratiometric fluorescence approach using chromophore-modified gold nanoclusters was developed for the rapid screening of drug-induced acute kidney injury, allowing for the quantification of fluctuation of ROS level in the kidneys to evaluate the risk of nephrotoxicity. The method demonstrated the screening of early renal injury induced by nephrotoxic triptolide and identification of other nephrotoxic components from herbal medicine such as aristolochine.

NANOSCALE (2021)

Article Nanoscience & Nanotechnology

Gold Nanoclusters Perform Enzyme-like Photocatalysis for Prodrug Activation

Rong Liu et al.

Summary: Synthetic nanomaterials known as nanozymes can catalyze biological transformations, and photonanozymes utilize light for spatial and temporal control. A gold nanocluster modified with glutathione serves as a photonanozyme, catalyzing the reduction of nitrobenzene under light and showing potential as a biocompatible catalyst in mammalian cells. This study reinvents gold nanoclusters as photonanozymes, mimicking natural nitroreductases for potential prodrug activation.

ACS APPLIED NANO MATERIALS (2021)

Article Chemistry, Multidisciplinary

Nucleic acid-driven aggregation-induced emission of Au nanoclusters for visualizing telomerase activity in living cells and in vivo

Xiang Ran et al.

Summary: A novel probe based on Au nanoclusters with aggregation-induced emission property was developed for sensitive telomerase detection in living cells and solid tumor tissue. This study provided insight into the specific connection mechanism of metal nanoclusters for AIE generation and shows great potential for disease detection both in vitro and in vivo.

MATERIALS HORIZONS (2021)

Article Materials Science, Biomaterials

Responsive hyaluronic acid-gold cluster hybrid nanogel theranostic systems

Ying Lin et al.

Summary: The smart fluorescent hyaluronic acid nanogel designed in this study successfully targeted tumor therapy in response to the reducing tumor microenvironment, demonstrating excellent drug loading capacity and fluorescence tracking ability.

BIOMATERIALS SCIENCE (2021)

Article Chemistry, Analytical

Aggregation-induced emission enhancement of gold nanoclusters in metal-organic frameworks for highly sensitive fluorescent detection of bilirubin

Mengfan Xia et al.

Summary: A fluorescence analysis method based on gold nanocluster and metal-organic framework composite materials was established for highly sensitive detection of bilirubin. The composite material displayed enhanced fluorescence properties, with a significant improvement in quantum yield and fluorescence lifetime compared to AuNCs alone. The method showed selective response and high sensitivity, making it suitable for clinical diagnosis.

ANALYST (2021)

Article Materials Science, Biomaterials

Coassembly of nucleus-targeting gold nanoclusters with CRISPR/Cas9 for simultaneous bioimaging and therapeutic genome editing

Yu Tao et al.

Summary: The study introduces protamine-capped gold nanoclusters as an effective CRISPR/Cas9 delivery tool for achieving successful gene editing and cancer therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Chemistry, Multidisciplinary

Electrocatalytic and photocatalytic applications of atomically precise gold-based nanoclusters

Yongnan Sun et al.

Summary: Gold nanoclusters with precise composition and tunable structure exhibit unexpected photocatalytic and electrocatalytic activities. They have potential applications in hydrogen evolution, oxygen reduction, CO2 reduction, and various photocatalytic reactions. Their unique geometrical and electronic properties make them promising in the catalytic field.

SCIENCE CHINA-CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Supramolecular-Macrocycle-Based Crystalline Organic Materials

Yujuan Zhou et al.

ADVANCED MATERIALS (2020)

Article Oncology

Precise therapeutic effect of self-assembling gold nanocluster-PTEN complexes on an orthotropic model of liver cancer

Maonan Wang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Article Chemistry, Physical

Novel enzymatic synthesis of core/shell AgNP/AuNC bimetallic nanostructure and its catalytic applications

A. Vinotha Alex et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

Article Chemistry, Physical

Incorporating of gold nanoclusters into metal-organic frameworks for highly sensitive detection of 3-nitrotyrosine as an oxidative stress biomarker

Roghayeh Jalili et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2020)

Article Multidisciplinary Sciences

In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition

Maonan Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Spectroscopy

Wet-spinning of fluorescent fibers based on gold nanoclusters-loaded alginate for sensing of heavy metal ions and anti-counterfeiting

Ying He et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

Article Chemistry, Multidisciplinary

Biodegradable Gold Nanoclusters with Improved Excretion Due to pH-Triggered Hydrophobic-to-Hydrophilic Transition

Elizabeth M. Higbee-Dempsey et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Physical

Structure regulated catalytic performance of gold nanocluster-MOF nanocomposites

Yanfei Zhu et al.

NANO RESEARCH (2020)

Article Nanoscience & Nanotechnology

Efficient Ambient Electrocatalytic Ammonia Synthesis by Nanogold Triggered via Boron Clusters Combined with Carbon Nanotubes

Xue Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Material-Selective Polydopamine Coating in Dimethyl Sulfoxide

Hong K. Park et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Chemistry, Multidisciplinary

Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Mohsin Ali Badshah et al.

NANOMATERIALS (2020)

Article Physics, Multidisciplinary

Defective Titanium Dioxide-supported Ultrasmall Au Clusters for Photocatalytic Hydrogen Production

Xiaoqin Zhang et al.

FRONTIERS IN PHYSICS (2020)

Review Materials Science, Multidisciplinary

Photo-Responsive Fluorescent Materials with Aggregation-Induced Emission Characteristics

Weihua Luo et al.

ADVANCED OPTICAL MATERIALS (2020)

Review Materials Science, Biomaterials

Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections

Dan Li et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Chemistry, Multidisciplinary

One-pot synthesis of β-cyclodextrin modified Au nanoclusters with near-infrared emission

Wenjing Li et al.

CHEMICAL COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Ligand-free gold nanoclusters confined in mesoporous silica nanoparticles for styrene epoxidation

Buthainah Al-Shankiti et al.

NANOSCALE ADVANCES (2020)

Article Chemistry, Multidisciplinary

Dendritic silica with carbon dots and gold nanoclusters for dual nanozymes

Lirong Zhao et al.

NEW JOURNAL OF CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Cucurbiturils brighten Au nanoclusters in water

Tao Jiang et al.

CHEMICAL SCIENCE (2020)

Editorial Material Multidisciplinary Sciences

Branched-chain amino acids in disease

Phillip J. White et al.

SCIENCE (2019)

Article Chemistry, Analytical

Metal-enhanced fluorescence of gold nanoclusters as a sensing platform for multi-component detection

Dang-Dang Xu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Spectroscopy

Colorimetric sensing towards spermine based on supramolecular pillar [5]arene reduced and stabilized gold nanoparticles

Xiaoping Tan et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2019)

Article Chemistry, Multidisciplinary

Atomically Precise Metal Nanoclusters for Catalysis

Xiangsha Du et al.

ACS NANO (2019)

Review Chemistry, Analytical

Recent progress in copper nanocluster-based fluorescent probing: a review

Taiping Qing et al.

MICROCHIMICA ACTA (2019)

Review Chemistry, Multidisciplinary

Metal Nanoclusters Stabilized by Selenol Ligands

Xi Kang et al.

SMALL (2019)

Article Nanoscience & Nanotechnology

Gold Nanocluster-Decorated Nanocomposites with Enhanced Emission and Reactive Oxygen Species Generation

Junhan Xia et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Chemistry, Multidisciplinary

Recent advances in ultra-small fluorescent Au nanoclusters toward oncological research

Jingjing Yang et al.

NANOSCALE (2019)

Article Chemistry, Multidisciplinary

Template protection of gold nanoclusters for the detection of organophosphorus pesticides

Huan Li et al.

NEW JOURNAL OF CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Luminescent Gold Nanocluster-Decorated Polymeric Hybrid Particles with Assembly-Induced Emission

Mathew Hembury et al.

BIOMACROMOLECULES (2018)

Article Chemistry, Physical

Preparation of fluorescent nanocomposites based on gold nanoclusters self-assembly

Xiaoyu Wang et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

Review Chemistry, Multidisciplinary

Coronarenes: recent advances and perspectives on macrocyclic and supramolecular chemistry

Mei-Xiang Wang

SCIENCE CHINA-CHEMISTRY (2018)

Article Spectroscopy

Distance dependent fluorescence quenching and enhancement of gold nanoclusters by gold nanoparticles

Haiyan Qin et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)

Article Chemistry, Physical

Cyclodextrin-gold nanocluster decorated TiO2 enhances photocatalytic decomposition of organic pollutants

Haiguang Zhu et al.

JOURNAL OF MATERIALS CHEMISTRY A (2018)

Article Materials Science, Biomaterials

Chitosan-Stabilized Self-Assembled Fluorescent Gold Nanoclusters for Cell Imaging and Biodistribution in Vivo

Ying Duan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Article Materials Science, Biomaterials

Chitosan-Stabilized Self-Assembled Fluorescent Gold Nanoclusters for Cell Imaging and Biodistribution in Vivo

Ying Duan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Article Chemistry, Multidisciplinary

In Situ Assembly of Au Nanoclusters within Protein Hydrogel Networks

Liqiang Wang et al.

CHEMISTRY-AN ASIAN JOURNAL (2017)

Article Chemistry, Physical

Hydrophobicity of Gold Nanoclusters Influences Their Interactions with Biological Barriers

Estelle Porret et al.

CHEMISTRY OF MATERIALS (2017)

Review Chemistry, Multidisciplinary

Metal nanoclusters: New fluorescent probes for sensors and bioimaging

Libing Zhang et al.

NANO TODAY (2014)

Article Chemistry, Multidisciplinary

From Aggregation-Induced Emission of Au(I)-Thiolate Complexes to Ultrabright Au(0)@Au(I)-Thiolate Core-Shell Nanoclusters

Zhentao Luo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Chemistry, Multidisciplinary

Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications

Li Shang et al.

NANO TODAY (2011)

Review Chemistry, Multidisciplinary

Fluorescent silver nanoclusters

Isabel Diez et al.

NANOSCALE (2011)

Review Chemistry, Multidisciplinary

Quantum sized, thiolate-protected gold nanoclusters

Rongchao Jin

NANOSCALE (2010)

Article Chemistry, Multidisciplinary

Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

Yonggang Ke et al.

NANO LETTERS (2009)

Article Chemistry, Multidisciplinary

Do special noncovalent pi-pi stacking interactions really exist?

Stefan Grimme

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Multidisciplinary Sciences

Folding DNA to create nanoscale shapes and patterns

PWK Rothemund

NATURE (2006)

Article Chemistry, Multidisciplinary

MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes

Y Miyake et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)