Journal
ACS MATERIALS LETTERS
Volume 4, Issue 8, Pages 1493-1502Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmaterialslett.2c00451
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Funding
- NSFC/China [21878087, 21908060]
- National Key Research and Development Program [2021YFA0910000]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) [2021 Sci Tech 03-28]
- A*STAR [A2083c0051]
- Ministry of Education, Singapore [MOE-MOET2EP101200007]
- Singapore University of Technology and Design [SUTD-ZJU (VP)201905]
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This study proposes a pi-conjugated crossbreeding dyad strategy to develop novel NIR-II dyes with small molecular weights, high stability, and good brightness, greatly expanding the high-resolution activatable in vivo imaging tools for intact tissues and living animals.
High-performance near-infrared-II (NIR-II) fluorophores have attracted tremendous attention for in vivo dynamic bioimaging. However, the lack of stable, bright, and biocompatible molecular fluorophores becomes a major barrier on the way to the widespread endorsement of NIR-II bioimaging for clinic diagnosis. Here we propose a pi-conjugated crossbreeding dyad strategy to develop novel desirable NIR-II dyes, flavchromenes (flav+chromene) integrated from two individual fluorophores of flavylium and chromene via a short methine bridge, affording valuable features of extending spectra into the NIR-II region and conferring a substantive leap in the photophysical properties. Notably, these crossbreeding NIR-II dyes have small molecular weights, high molar extinction coefficients, and outstanding chemical stability. As demonstrated, the elaborated probe Flavchrom-4 endows activatable dual-modal in vivo imaging of endogenous ss-galactosidase activity, along with lighting-up NIR-II fluorescence signals and dramatically enhanced photoacoustic signals (16.3-fold). This concise pi-conjugated crossbreeding dyad strategy brings forth high-performance NIR-II fluorophore scaffolds with small molecular weights, high stability, and good brightness, thus greatly expanding high-resolution activatable in vivo imaging tools for intact tissues and living animals.
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