Enhanced Depth SD-OCT Images Reveal Characteristic Choroidal Changes in Patients With Vogt-Koyanagi-Harada Disease

BACKGROUND AND OBJECTIVE: To identify characteristic choroidal changes of patients with Vogt-Koyanagi-Harada (VKH) disease at different stages. PATIENTS AND METHODS: Fifty-four patients with VKH in the acute uveitic or convalescent stages, 24 patients with central serous chorioretinopathy (CSC), and 54 normal participants were enrolled in this prospective, observational study. Enhanced depth imaging spectral-domain optical coherence tomography scans were captured for all subjects to allow for comparison of choroidal morphological findings. RESULTS: Numerous round or oval hyperreflective profiles with hyporeflective cores, corresponding to choroidal vessels, were observed in the choroid of control participants and patients with CSC; whereas the numbers of these profiles were markedly decreased in the choroid of VKH patients in both the acute uveitic and convalescent stages. CONCLUSION: A reduction in vascular profiles in the choroid is observed in VKH and may aid in the differentiation with disorders such as CSC.