Journal
ONCOLOGY RESEARCH AND TREATMENT
Volume 39, Issue 10, Pages 622-+Publisher
KARGER
DOI: 10.1159/000449326
Keywords
Breast; Carcinoma; Receptor for advanced glycation end-products; Tumor
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Funding
- Hamadan University of Medical Science [9312126511]
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Background: The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. Methods: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. Results: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). Conclusions: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression. (C) 2016 S. Karger GmbH, Freiburg
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