4.5 Article

Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

Lulu Sun et al.

Summary: FXR plays a crucial role in metabolic diseases and gastrointestinal and liver cancers by regulating bile acid synthesis and enterohepatic circulation, influencing glucose and lipid homeostasis. Targeting FXR signaling and bile acid metabolites may provide potential strategies for prevention and treatment of gastrointestinal and liver cancers.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Toxicology

Depletion of serotonin relieves concanavalin A-induced liver fibrosis in mice by inhibiting inflammation, oxidative stress, and TGF-β1/Smads signaling pathway

Qing Pang et al.

Summary: In this study, serotonin depletion significantly inhibited Con A-induced liver fibrosis by reducing inflammation and oxidative stress, as well as inhibiting the TGF-beta 1/Smads signaling pathway.

TOXICOLOGY LETTERS (2021)

Review Biochemistry & Molecular Biology

Farnesoid X receptor (FXR): Structures and ligands

Longying Jiang et al.

Summary: FXR is a crucial bile acid activated nuclear receptor that regulates key genes involved in bile acid metabolism. With the approval of OCA as the first small molecule targeting FXR, many other FXR-targeting small molecules are currently being evaluated in clinical trials.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Masayoshi Kage et al.

JOURNAL OF MEDICAL ULTRASONICS (2020)

Review Gastroenterology & Hepatology

NAFLD Epidemiology, Emerging Pharmacotherapy, Liver Transplantation Implications and the Trends in the United States

Chiranjeevi Gadiparthi et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease - A global public health perspective

Zobair M. Younossi

JOURNAL OF HEPATOLOGY (2019)

Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article

Bile Acid Metabolism in Liver Pathobiology

John Y. L. Chiang et al.

GENE EXPRESSION (2018)

Review Gastroenterology & Hepatology

Lipotoxicity and the gut-liver axis in NASH pathogenesis

Fabio Marra et al.

JOURNAL OF HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

Cynthia Lebeaupin et al.

JOURNAL OF HEPATOLOGY (2018)

Article Biochemistry & Molecular Biology

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Ju Youn Kim et al.

Article Gastroenterology & Hepatology

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease

Frank J. Gonzalez et al.

DIGESTIVE DISEASES (2017)

Review Gastroenterology & Hepatology

An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease

Frank J. Gonzalez et al.

GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Pathogenesis of Nonalcoholic Steatohepatitis

Mariana Verdelho Machado et al.

GASTROENTEROLOGY (2016)

Article Medicine, Research & Experimental

C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis

Khalidur Rahman et al.

LABORATORY INVESTIGATION (2016)

Article Endocrinology & Metabolism

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Elena Buzzetti et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Biochemistry & Molecular Biology

Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice

Yunpeng Qi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)

Review Gastroenterology & Hepatology

Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways

Carmen Garcia-Ruiz et al.

JOURNAL OF HEPATOLOGY (2015)

Article Medicine, Research & Experimental

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Cell Biology

A Ceramide-Centric View of Insulin Resistance

Jose A. Chavez et al.

CELL METABOLISM (2012)

Article Gastroenterology & Hepatology

High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism

Lisa Longato et al.

HEPATOLOGY RESEARCH (2012)

Review Endocrinology & Metabolism

Role of ceramides in nonalcoholic fatty liver disease

Mangesh Pagadala et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

Article Medicine, Research & Experimental

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

William L. Holland et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Article Endocrinology & Metabolism

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

Jin Seo et al.

DIABETES (2009)

Article Biochemistry & Molecular Biology

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Insook Kim et al.

JOURNAL OF LIPID RESEARCH (2007)