4.6 Article

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Rameshwar S. Cheke et al.

Summary: Isatin and its derivatives have diverse pharmacological activities and potential as therapeutic agents. Researchers utilize the structure of isatins to design analogues with enhanced biological activity. This review presents the recent developments of isatin analogues from 2016 to 2020 and discusses the structure-activity relationship.

PHARMACEUTICALS (2022)

Review Chemistry, Medicinal

Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents

Pezhman Shiri

Summary: Triazole ring is a cyclic scaffold with three nitrogen heteroatoms that exhibit diverse biological activities. The hybrid approach is an innovative tool for synthesizing multiple entities in one molecule with novel biological properties. Various synthetic protocols exist for beta-lactam synthesis, with the Staudinger reaction being a successful strategy.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Review Immunology

Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis

Sarah E. Murphy et al.

Summary: This review presents current antifungal drugs for Candida infections, discusses mechanisms of resistance, introduces novel antifungal agents under development, and explores the use of combination therapy as a potential strategy against emerging drug-resistant Candida.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Infectious Diseases

Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis

Henrique Pinto et al.

Summary: This study highlights the close relationship between biofilms and the resistance and virulence of BSI and UTI infections, especially the association of resistant strains with BSI persistence and mortality. The impact of biofilms on Candida BSI appears to be independent of clinical differences, including treatment interventions. In UTI, multi-drug resistant and extended-spectrum beta-lactamase-producing strains of Escherichia coli are associated with higher prevalence of biofilm production.

ANTIBIOTICS-BASEL (2021)

Review Chemistry, Medicinal

Isatin derivatives and their anti-bacterial activities

Hua Guo

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Physical

Design, synthesis and antibacterial activity of isatin derivatives as FtsZ inhibitors

Zhi-Min Lian et al.

JOURNAL OF MOLECULAR STRUCTURE (2016)

Article Chemistry, Multidisciplinary

Are the physicochemical properties of antibacterial compounds really different from other drugs?

Jean-Paul Ebejer et al.

JOURNAL OF CHEMINFORMATICS (2016)

Review Chemistry, Medicinal

Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties

Mirta L. Fascio et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives

Mohammed S. Abdel-Maksoud et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Chemopreventive and antioxidant activity of 6-substituted imidazo [2,1-b]thiazoles

Aldo Andreani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Review Pharmacology & Pharmacy

The design and development of imidazothiazole-chalcone derivatives as potential anticancer drugs

Ahmed Kamal et al.

EXPERT OPINION ON DRUG DISCOVERY (2013)

Review Microbiology

Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions

Georgina Cox et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2013)

Article Chemistry, Medicinal

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]

Aldo Andreani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety

Nuray Ulusoy Guzeldemirci et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential

Priyankar Paira et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Biochemistry & Molecular Biology

In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4-substituted isatin-3-thiosemicarbazones

Humayun Pervez et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Rhodium-catalyzed asymmetric addition of aryl- and alkenylboronic acids to isatins

Ryo Shintani et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Review Microbiology

Molecular basis of bacterial outer membrane permeability revisited

H Nikaido

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2003)

Article Chemistry, Medicinal

Synthesis and antitubercular activity of imidazo[2,1-b] thiazoles

A Andreani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)