4.6 Article

Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 42, Pages 8187-8191

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob01647h

Keywords

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Funding

  1. Natural Science Foundation of Zhejiang Province of China [LQ20B020008]
  2. Cultivation Project of Taizhou University
  3. Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]

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A green and facile method for the synthesis of previously unreported compounds has been established. This method offers broad substrate scope, high yields, mild reaction conditions, and effortless work-up.
A green and facile synthesis of previously unreported C,N-disulfonated 5-amino pyrazoles was established through an iodine-catalyzed cascade reaction of easily accessible sulfonyl hydrazides, beta-ketonitriles, and sodium sulfinates. Diverse C,N-disulfonated 5-amino pyrazoles could be obtained in 38-88% yields. This methodology features green and mild conditions, broad substrate scope, and effortless work-up.

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