Journal
NEUROIMAGE-CLINICAL
Volume 11, Issue -, Pages 796-801Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2016.05.008
Keywords
Cerebrovascular Reactivity; BOLD signal; white matter hyperintensity; Dynamic response; Carbon dioxide
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Funding
- Canadian Stroke Network
- Ontario Research Fund [RE 02-002]
- Heart and Stroke Foundation Canadian Partnership for Stroke Recovery
- LC Campbell Foundation
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Purpose: To evaluate the relationship between both dynamic and steady-state measures of cerebrovascular reactivity (CVR) and the progression of age-related white matter disease. Methods: Blood oxygen level-dependent (BOLD) MRI CVR scans were acquired from forty-five subjects (age range: 50-90 years, 25 males) with moderate to severe white matter disease, at baseline and one-year follow-up. To calculate the dynamic (tau) and steady-state (ssCVR) components of the BOLD signal response, the PETCO2 signal waveform was convolved with an exponential decay function. The tau corresponding to the best fit between the convolved PETCO2 and BOLD signal defined the speed of response, and the slope of the regression between the convolved PETCO2 and BOLD signal defined ssCVR. ssCVR and tau were compared between normal-appearing white matter (NAWM) that remains stable over time and NAWM that progresses to white matter hyperintensities (WMHs). Results: In comparison to contralateral NAWM, NAWM that progressed to WMH had significantly lower ssCVR values by mean (SD) 46.5 (7.6)%, and higher tau values by 31.9 (9.6)% (both P < 0.01). Conclusions: Vascular impairment in regions of NAWM that progresses to WMH consists not only of decreased magnitude of ssCVR, but also a pathological decrease in the speed of vascular response. These findings support the association between cerebrovascular dysregulation and the development of WMH. (C) 2016 Published by Elsevier Inc.
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