Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis

Article Gastroenterology & Hepatology

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Jiang Li et al.

Summary: This study suggests that immune-metabolism disorder triggered by HBV exacerbation may be a potential mechanism of HBV-ACLF, providing a novel diagnostic and treatment target to reduce HBV-ACLF-related mortality.

GUT (2022)

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Article Gastroenterology & Hepatology

Prevalence and clinical significance of serum sodium variability in patients with acute-on-chronic liver diseases: a prospective multicenter study in China

Xue Mei et al.

Summary: This study aimed to investigate the prevalence of different sodium (Na) levels in hospitalized patients with acute-on-chronic liver disease (AoCLD) in China and their relationship with 90-day prognosis. The results showed that hyponatremia was an independent risk factor for poor 90-day prognosis in patients with AoCLD, and failure to correct hyponatremia within a week after admission was associated with increased mortality.

HEPATOLOGY INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure

Florence Wong et al.

Summary: Bacterial infections can trigger acute-on-chronic liver failure, with varying rates and clinical characteristics in different geographic regions, particularly with the highest incidence in the Indian subcontinent.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

A neutrophil-to-lymphocyte ratio-based prognostic model to predict mortality in patients with HBV-related acute-on-chronic liver failure

Jian Sun et al.

Summary: The study developed an NLR-based ACLF score, which showed superior prognostic value in predicting short-term mortality risk in patients with HBV-ACLF compared to existing models.

BMC GASTROENTEROLOGY (2021)

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Article Medicine, General & Internal

Cohort profile: a multicentre prospective validation cohort of the Chinese Acute-on-Chronic Liver Failure (CATCH-LIFE) study

Liang Qiao et al.

Summary: The CATCH-LIFE study aims to fill the gaps in research on acute-on-chronic liver failure, collecting a wealth of clinical information and samples through two phases of investigation and validation cohorts. Future plans involve comparing new ACLF diagnostic criteria derived from the validation cohort data with existing ones, as well as conducting proteomic and metabolic omics analyses to advance specific therapy development.

BMJ OPEN (2021)

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Article Gastroenterology & Hepatology

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Jonel Trebicka et al.

Summary: This study analyzed the precipitants leading to acute decompensation in cirrhosis patients, identifying proven bacterial infections and severe alcoholic hepatitis as the main causes. The number of precipitants was significantly associated with 90-day mortality, emphasizing the need for specific preventive and therapeutic strategies targeting these events.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Jiaqi Li et al.

Summary: A new prognostic score based on six predictors was developed to accurately predict short-term mortality in patients with HBV-ACLF. This score outperformed four other commonly used scores in terms of predictive ability.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

The global burden of cirrhosis: A review of disability-adjusted life-years lost and unmet needs

Peter Jepsen et al.

Summary: Cirrhosis is a significant burden on public health, with hepatitis C, alcohol, and hepatitis B being the main contributors globally. In poorer countries, hepatitis B infection is the primary cause, while alcohol and hepatitis C are dominant in more affluent countries.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Prevalence and Clinical Significance of Portal Vein Thrombosis in Patients With Cirrhosis and Acute Decompensation

Yan Zhang et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

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HEV superinfection accelerates disease progression in patients with chronic HBV infection and increases mortality in those with cirrhosis

Tai-Chung Tseng et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Jonel Trebicka et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Infectious Diseases

Is HBV viral load at admission associated with development of acute-on-chronic liver failure in patients with acute decompensation of chronic hepatitis B related cirrhosis?

Jian-Hua Lei et al.

BMC INFECTIOUS DISEASES (2019)

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Review Gastroenterology & Hepatology

Diagnosis and Treatment of Alcohol Use Disorder in Patients With End-Stage Alcoholic Liver Disease

Fabio Caputo et al.

HEPATOLOGY (2019)

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Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

Javier Fernandez et al.

GUT (2018)

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Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Tianzhou Wu et al.

GUT (2018)

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Characteristics of systemic inflammation in hepatitis B-precipitated ACLF: Differentiate it from No-ACLF

Wei Wu et al.

LIVER INTERNATIONAL (2018)

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Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality

Marcus M. Muecke et al.

LIVER INTERNATIONAL (2018)

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Article Public, Environmental & Occupational Health

Acute-on-Chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics

Wen-yi Gu et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2018)

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ACG Clinical Guideline: Alcoholic Liver Disease

Ashwani K. Singal et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2018)

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Neutrophil-to-Lymphocyte Ratio Associates Independently With Mortality in Hospitalized Patients With Cirrhosis

Jonathan Rice et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Norah A. Terrault et al.

HEPATOLOGY (2018)

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EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

JOURNAL OF HEPATOLOGY (2018)

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Article Multidisciplinary Sciences

Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B

Hai Li et al.

SCIENTIFIC REPORTS (2016)

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Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis

Thierry Gustot et al.

HEPATOLOGY (2015)

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Long-term effect of antiviral therapy on disease course after decompensation in patients with hepatitis B virus-related cirrhosis

Jeong Won Jang et al.

HEPATOLOGY (2015)

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Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults

Yu Shi et al.

HEPATOLOGY (2015)

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Liver cirrhosis

Emmanuel A. Tsochatzis et al.

LANCET (2014)

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Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

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GASTROENTEROLOGY (2013)

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Tenofovir Improves the Outcome in Patients with Spontaneous Reactivation of Hepatitis B Presenting as Acute-On-Chronic Liver Failure

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HEPATOLOGY (2011)

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Course of disease and survival after onset of decompensation in hepatitis B virus-related cirrhosis

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LIVER INTERNATIONAL (2010)

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Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis

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