Journal
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
Volume 18, Issue 4, Pages 873-879Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jcrt.JCRT_12_19
Keywords
Cancer; candidate genes; dietary habits; gastric carcinoma; Jammu and Kashmir; single-nucleotide polymorphism
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Funding
- Women Scientists Scheme-A, Department of Science and Technology, India [SR/WOS-A/LS1067/2015]
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Gastric carcinoma is a common malignancy with a heterogeneous nature, and its incidence is particularly high in the northeastern region and Kashmir Valley of India, possibly due to genetic factors.
Gastric Carcinoma (GC) is one of the most common malignancies, which accounts for 6.8% of total cancer population worldwide. In India, the northeastern region has the highest gastric cancer incidence, and the Kashmir Valley has a very high incidence of gastric cancer as compared to other parts of Northern India. It exceeds 40% of total cancers with an incidence rate of 3-6-fold higher than other metro cities of India. Gastric cancer is a heterogeneous disease where most of the cases are sporadic, and < 15% are due to obvious familial clustering. The heterogeneous nature of the disease can be associated with differences in genetic makeup of an individual. A better understanding of genetic predisposition toward GC will be helpful in promoting personalized medicine. The aim of this review is to analyze the development and progression of GC and to explore the genetic perspectives of the disease with special emphasis on Jammu and Kashmir, India.
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