Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 42, Pages 8212-8216Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob01710e
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Funding
- Ministry of Science and Technology in Taiwan [MOST109-2636-M-009-003, MOST110-2113-M-A49-001-MY2]
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In this study, a photoflow method was developed for the radical-based coupling of unactivated arenes and aryl chlorides. The reaction proceeded smoothly at ambient temperature without the need for metal catalysts. Importantly, the reaction conditions were optimized for chloroarenes with different electronic properties. Despite the generally lower reactivity of aryl chlorides compared to their iodide and bromide counterparts, the developed protocol efficiently converted readily available and inexpensive chloroarenes into unsymmetrical biaryl products.
A photoflow method is presented for a radical-based coupling of unactivated arenes and aryl chlorides. The process proceeded smoothly at ambient temperature under metal-free conditions. Of note is that the reaction conditions are fine-tuned for chloroarenes with different electronic properties. While the reactivity profile of aryl chlorides is generally known to be inferior to those of the corresponding iodides and bromides, we demonstrate that the title protocol is efficient in converting readily available and inexpensive chloroarenes into unsymmetrical biaryl products.
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