Related references
Note: Only part of the references are listed.ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation
Dongsheng Bai et al.
AUTOPHAGY (2022)
Adipose-tissue plasticity in health and disease
Alexander Sakers et al.
CELL (2022)
Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study
Qi Qiu et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2022)
FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis
Lintao Song et al.
HEPATOLOGY (2022)
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Teng Ma et al.
NATURE (2022)
Extricating human tumour immune alterations from tissue inflammation
Florian Mair et al.
NATURE (2022)
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Marisa R. Morrow et al.
CELL METABOLISM (2022)
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
Danielle L. Schmitt et al.
NATURE COMMUNICATIONS (2022)
Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
Pascale Gluais-Dagorn et al.
HEPATOLOGY COMMUNICATIONS (2022)
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1
Mengqi Li et al.
CELL RESEARCH (2021)
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels
Qian Zhang et al.
NATURE CELL BIOLOGY (2021)
An updated guide for the perplexed: cytometry in the high-dimensional era
Thomas Liechti et al.
NATURE IMMUNOLOGY (2021)
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
Joshua C. Drake et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
Feng Wang et al.
NATURE COMMUNICATIONS (2021)
Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy
Doudou Huang et al.
ADVANCED SCIENCE (2021)
Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo- controlled, phase 2a study
Kenneth Cusi et al.
LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)
Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study
Pascale Fouqueray et al.
CELL REPORTS MEDICINE (2021)
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
Asier Gonzalez et al.
CELL METABOLISM (2020)
Two conserved epigenetic regulators prevent healthy ageing
Jie Yuan et al.
NATURE (2020)
An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Peng Zhao et al.
SCIENCE (2020)
Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer
G. Du Preez et al.
SCIENTIFIC REPORTS (2020)
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Kelvin Yen et al.
AGING-US (2020)
Quantitative Fluxomics of Circulating Metabolites
Sheng Hui et al.
CELL METABOLISM (2020)
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans
Lilia Espada et al.
NATURE METABOLISM (2020)
iProX: an integrated proteome resource
Jie Ma et al.
NUCLEIC ACIDS RESEARCH (2019)
Retire statistical significance
Valentin Amrhein et al.
NATURE (2019)
AMP-activated protein kinase: the current landscape for drug development
Gregory R. Steinberg et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress
Yue Zong et al.
CELL RESEARCH (2019)
AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction
Rasmus Kjobsted et al.
DIABETES (2019)
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondria! Fragmentation in Obesity
Philipp Hammerschmidt et al.
CELL (2019)
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
Mengqi Li et al.
CELL METABOLISM (2019)
The flight response impairs cytoprotective mechanisms by activating the insulin pathway
Maria Jose De Rosa et al.
NATURE (2019)
Targeting a moonlighting function of aldolase induces apoptosis in cancer cells
Agnieszka Gizak et al.
CELL DEATH & DISEASE (2019)
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Daniel Garcia et al.
CELL REPORTS (2019)
Moving to a World Beyond p < 0.05
Ronald L. Wasserstein et al.
AMERICAN STATISTICIAN (2019)
Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status
Patricia Marques et al.
CELL DEATH DISCOVERY (2019)
AMPK: guardian of metabolism and mitochondrial homeostasis
Sebastien Herzig et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Promise and challenges for direct small molecule AMPK activators
Severine Olivier et al.
BIOCHEMICAL PHARMACOLOGY (2018)
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity
Hui Luo et al.
CELL METABOLISM (2018)
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
Nadia Boudaba et al.
EBIOMEDICINE (2018)
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
Ryan M. Esquejo et al.
EBIOMEDICINE (2018)
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
Mohammad Bagherniya et al.
AGEING RESEARCH REVIEWS (2018)
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Roger W. Hunter et al.
NATURE MEDICINE (2018)
Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase
Paul W. Heron et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
Par Steneberg et al.
JCI INSIGHT (2018)
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
Xin Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II
Sandra Markmann et al.
MOLECULAR & CELLULAR PROTEOMICS (2017)
Blocking FSH induces thermogenic adipose tissue and reduces body fat
Peng Liu et al.
NATURE (2017)
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Chen-Song Zhang et al.
NATURE (2017)
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Robert W. Myers et al.
SCIENCE (2017)
AMPK as a Therapeutic Target for Treating Metabolic Diseases
Emily A. Day et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet
Angela Woods et al.
CELL REPORTS (2017)
Metformin extends C. elegans lifespan through lysosomal pathway
Jie Chen et al.
ELIFE (2017)
AMP-Activated Protein Kinase An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System
Ian P. Salt et al.
CIRCULATION RESEARCH (2017)
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging
Sung-Jun Park et al.
CELL METABOLISM (2017)
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue
Xiaoyan Hui et al.
EMBO REPORTS (2017)
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice
Emily C. Cokorinos et al.
CELL METABOLISM (2017)
AMPK signalling in health and disease
David Carling
CURRENT OPINION IN CELL BIOLOGY (2017)
Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target
Geoffrey Grandjean et al.
CANCER RESEARCH (2016)
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu et al.
CELL (2016)
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
Lianfeng Wu et al.
CELL (2016)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang et al.
CELL METABOLISM (2016)
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function
Arash Yavari et al.
CELL METABOLISM (2016)
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1
Brennan K. Smith et al.
DIABETES (2016)
Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise
Rasmus Kjobsted et al.
DIABETES (2016)
Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2
Dewei Ye et al.
JOURNAL OF HEPATOLOGY (2016)
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang et al.
SCIENCE (2016)
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Rebecca J. Ford et al.
BIOCHEMICAL JOURNAL (2015)
Mitochondria as Targets of Drug Toxicity: Lessons From the R118 Phase I Experience
E. P. Brass et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)
Toxicity of a Novel Therapeutic Agent Targeting Mitochondrial Complex I
C. C. Low Wang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)
Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt
Amrita M. Nargund et al.
MOLECULAR CELL (2015)
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity
Jing Geng et al.
NATURE IMMUNOLOGY (2015)
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
Jiyong Liang et al.
NATURE COMMUNICATIONS (2015)
The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
Chen-Song Zhang et al.
CELL METABOLISM (2014)
AMPK at the Nexus of Energetics and Aging
Kristopher Burkewitz et al.
CELL METABOLISM (2014)
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
Wouter De Haes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
Alexander A. Shestov et al.
ELIFE (2014)
Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment
Jason R. Clapper et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice
Mingliang Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
What is the total number of protein molecules per cell volume? A call to rethink some published values
Ron Milo
BIOESSAYS (2013)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes et al.
CELL (2013)
Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
Joungmok Kim et al.
CELL (2013)
AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
Ya-Lin Zhang et al.
CELL METABOLISM (2013)
Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity
Martin Friedrichsen et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D. Fullerton et al.
NATURE MEDICINE (2013)
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo et al.
NATURE COMMUNICATIONS (2013)
Quality assurance for polychromatic flow cytometry using a suite of calibration beads
Stephen P. Perfetto et al.
NATURE PROTOCOLS (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Simon A. Hawley et al.
SCIENCE (2012)
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li et al.
CELL METABOLISM (2011)
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
Peter Bai et al.
CELL METABOLISM (2011)
Clinical Pharmacokinetics of Metformin
Garry G. Graham et al.
CLINICAL PHARMACOKINETICS (2011)
Stimulation of Human Whole-Body Energy Expenditure by Salsalate Is Fueled by Higher Lipid Oxidation under Fasting Conditions and by Higher Oxidative Glucose Disposal under Insulin-Stimulated Conditions
Ruth C. R. Meex et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Structure of mammalian AMPK and its regulation by ADP
Bing Xiao et al.
NATURE (2011)
Global quantification of mammalian gene expression control
Bjoern Schwanhaeusser et al.
NATURE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
In situ Measurement of the Electrical Potential Across the Lysosomal Membrane Using FRET
Mirkka Koivusalo et al.
TRAFFIC (2011)
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes A Randomized Trial
Allison B. Goldfine et al.
ANNALS OF INTERNAL MEDICINE (2010)
Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme
Rafael F. Say et al.
NATURE (2010)
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
Jonathan S. Oakhill et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
Christian Pehmoller et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells
Mariusz R. Wieckowski et al.
NATURE PROTOCOLS (2009)
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
Shuai Chen et al.
BIOCHEMICAL JOURNAL (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman et al.
NATURE BIOTECHNOLOGY (2008)
Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells
Andrey V. Kuznetsov et al.
NATURE PROTOCOLS (2008)
Structural basis for AMP binding to mammalian AMP-activated protein kinase
Bing Xiao et al.
NATURE (2007)
AMP-activated protein kinase in the heart - Role during health and disease
Michael Arad et al.
CIRCULATION RESEARCH (2007)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry
Sunil U. Bajad et al.
JOURNAL OF CHROMATOGRAPHY A (2006)
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
Barbara Cool et al.
CELL METABOLISM (2006)
High resolution reaction intermediates of rabbit muscle fructose-1,6-bisphosphate aldolase - Substrate cleavage and induced fit
M St-Jean et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
A Woods et al.
CELL METABOLISM (2005)
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley et al.
CELL METABOLISM (2005)
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
DE Kleiner et al.
HEPATOLOGY (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Separation and characterization of late endosomal membrane domains
T Kobayashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases
A Maurady et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Snapshots of catalysis: The structure of fructose-1,6-(bis)phosphate aldolase covalently bound to the substrate dihydroxyacetone phosphate
KH Choi et al.
BIOCHEMISTRY (2001)
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
MS Yuan et al.
SCIENCE (2001)
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
AS Marsin et al.
CURRENT BIOLOGY (2000)
Share Paper
