Journal
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
Volume 35, Issue 9, Pages 854-+Publisher
CHINESE CENTER DISEASE CONTROL & PREVENTION
DOI: 10.3967/bes2022.109
Keywords
MicroRNAs; HRV16; Targets
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In this study, we investigated the changes in miRNA levels in HRV16-infected cells and found associations between differentially expressed miRNAs and genes associated with cellular differentiation and transcriptional regulation.
In the present study we investigated the changes in miRNA levels inhuman rhinovirus 16 (HRV16)-infected cells. A small RNA deep sequencing experiment was performed through next-generation sequencing. In total, 53 differentially expressed miRNAs were confirmed by RT-qPCR, including 37 known miRNAs and 16 novel miRNAs. Interaction networks between differentially expressed miRNAs and their targets were established by mirDIP and Navigator. The prediction results showed that QKI, NFAT5, BNC2, CELF2, LCOR, MBNL2, MTMR3, NFIB, PPARGC1A, RSBN1, TRPS1, WDR26, and ZNF148, which are associated with cellular differentiation and transcriptional regulation, were recognized by 12, 11, or 9 miRNAs. Many correlations were observed between transcriptional or post-transcriptional regulation of an miRNA and the expression levels of its target genes in HRV16-infected H1-HeLa cells.
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