The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging.

Automated summary

Recent research on intestinal microbiota and its impact on the central nervous system has gained significant attention. Changes in the gut microbiota due to aging can lead to brain aging and neurodegenerative diseases. Maintaining a healthy gut microbiota is crucial for overall health and aging, as dysbiosis can contribute to various chronic diseases. Understanding the mechanisms underlying gut microbiota changes will help identify biomarkers for aging-related conditions.