Journal
ANALYTICAL METHODS
Volume 14, Issue 42, Pages 4245-4251Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ay01170k
Keywords
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Funding
- Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi [2019L0759, 2021L368]
- Cultivate Scientific Research Excellence Programs of Higher Education Institutions in Shanxi [2020KJ023]
- Shanxi Scholarship Council of China [2020-133, 2021-144]
- Innovation & Entrepreneurship Training Program for College Students in Shanxi Province [2021-585]
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Two kinds of copper-based metal fluorescent nanoclusters were prepared using chemical reduction method, one by direct reduction of copper sulfate and the other by stepwise addition of copper salt and chloroauric acid. CuNCs were used for fluorescence resonance energy transfer (FRET) system with NR, while CuAuNCs acted as fluorescent probes for vanillin detection through quenching mechanism.
Two kinds of copper-based metal fluorescent nanoclusters were successfully prepared by the chemical reduction method; one of them (CuNCs) was synthesized by direct reduction of copper sulfate, and the other (CuAuNCs) was synthesized by the stepwise addition of copper salt and chloroauric acid. CuNCs were used to establish the fluorescence resonance energy transfer (FRET) system with neutral red (NR) due to the supramolecular effect of beta-cyclodextrin (beta-CD) modified on the surface of CuNCs. NR could enter the hydrophobic cavity of beta-CD and narrow the distance between CuNCs and NR, which could lead to FRET. Fluorescence was transferred from CuNCs to NR, resulting in amplification of the NR fluorescence signal, which could be used to detect vanillin. In addition, CuAuNCs with strong fluorescence were used as fluorescent probes to detect vanillin through the quenching mechanism. By comparison, the simplicity of CuNC synthesis and the high selectivity of beta-CD made the FRET method more practical, which may provide a new strategy for assaying vanillin.
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