Sono-assembly of nanostructures via tyrosine-tyrosine coupling reactions at the interface of acoustic cavitation bubbles

This work demonstrates that the reactive and oscillating surface of acoustic cavitation microbubbles acts as a catalytic binding site for the coupling of amphiphilic biomolecules bearing tyrosine moieties at the gas-liquid interface. We show a one-step, controlled ultrasonic process to self assemble tyrosine moieties into highly fluorescent uniformly sized sub-micron particles with new optical and functional properties.