Journal
MATERIALS HORIZONS
Volume 3, Issue 6, Pages 556-562Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6mh00307a
Keywords
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Funding
- National Natural Science Foundation of China [21574093, 21334004, 21404076]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Natural Sciences and Engineering Research Council of Canada
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A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. The concept is realized using a tissue plasminogen activator (t-PA)-loaded hydrogel crosslinked by a thrombin-cleavable peptide. The hydrogel is shown to release t-PA in serum and dissolve fibrin clots only when thrombin (generated during clot formation) is present.
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